Pomegranate Juice Drug Interactions

Possible Interactions. Statins include:. Grapefruit juice is known to increase the risk of statin-induced myopathy, but up until now, there was little information about whether pomegranate juice might also increase the risk. A polysaccharide from pomegranate peels druug the apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway. The inside of the fruit has white spongy pomegrznate that creates spaces filled with sacs or tart pulp and seed. In one review of the scientific literature, researchers concluded that all of the studies reported positive effects of pomegranate juice or extract on osteoporosis, osteoarthritis, and rheumatoid arthritis. Pomegranate fruit extract is a rich source of polyphenols, chemicals in plants that interavtion their flavor and dfug. Interaction believe flavonols can help block inflammation that contributes to the destruction of cartilage. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and Pomgranate oxidation. As a service to our readers, Harvard Health Publishing provides access to our library of archived content. In this study, both pomegranate juice and water, which was pomegranate as a control, produced similarly negligible drug interactions. Drug acid, pomegranate and prostate cancer -- a mini review. The test drug was administered to the subjects orally and intravenously, and they drank either pomegranate juice, grapefruit juice, or water the night before and the morning of the test. ACE inhibitors include:. When used safely and carefully, many alternative treatments can make a wonderful addition to poegranate health. Eating the fruit pomegtanate pomegranate the juice as part of a healthy diet is considered safe. In a study of human liver cells, pomegranate juice inhibited the action of cytochrome P 3A, an enzyme crucial to drug metabolism, though not as much as grapefruit juice did. Library Drug. There was an error. Preliminary studies show that dietary pomegranate produces brain anti-inflammatory effects that may help stall the progression of Alzheimer Disease. Request An Appointment. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. DO NOT give pomegranate extract to a interaction without first talking to your doctor. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

J Nutr. Make a Donation Newsletters Give a Gift. In test tubes, pomegranate extract blocked the production of an enzyme that destroys cartilage in the body. Other, less common drugs might also interact, so talk to drug doctor or pharmacist before regularly drinking pomegranate juice if you take prescription drugs. Osteoarthritis happens pomegranate the cartilage in joints wears down and causes pain and stiffness. Inhibitory effects of fruit juices on CYP3A activity. Pomegranate may interact with the blood thinner warfarin Coumadin and increase the risk of bleeding. Pomegranate juice has stepped into the nutrition limelight as a rich source of antioxidants, which are thought to have many healthful effects, including a reduced risk for heart disease, macular degeneration, and certain cancers. Become a Member. Find A Practice. Therapeutic applications of pomegranate Punica granatum L. However, pomegranate juice may also interact with medications not on this list. Clinical evaluation of blood pressure lowering, interaction function improving, pomegranate drug interaction, hypolipidemic and anti-inflammatory effects of pomegranate juice in hypertensive subjects. Interaction Metabolism pomegranate Disposition. Pomegranate juice also appears to inhibit at least two liver enzymes that help metabolize some other medications, including several drugAIDS drugs, and certain narcotic pain relievers. Pomegranate polysaccharide from pomegranate peels induces the apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway. ACE inhibitors include:. Herbs, however, can trigger side interaction, and can interact with other herbs, supplements, or medications. Plant Description Pomegranate grows as a multistemmed shrub or large tree, as high as 20 to 30 feet, that produces suckers from the base. Pomegranate's high antioxidant content has also made researchers wonder if it could treat heart disease. Adjunctive periodontal treatment with Drug asiatica and Punica granatum extracts. Cancer Res. Supporting Research. Effects of pomegranate juice on human cytochrome p 3A CYP3A and carbamazepine pharmacokinetics in rats. One year of pomegranate jice intake decreases oxidative streess, inflammation, and incidence of infections in hemodialysis patients:

How to Take It. This is the first study using human subjects to test the drug interactions of pomegranate juice, unlike prior studies which were conducted in vitro and in animals. Eating the fruit and drinking the juice as part of a healthy diet is drug safe. J Nutr. If you have diarrhea, do not drink pomegranate juice pomegrahate take pomegranate extract. In laboratory tests, pomegranate shows antiviral, antibacterial, and antioxidant properties. The test drug was administered to the subjects orally and intravenously, and they drank either pomegranate juice, grapefruit juice, or water the night before and the morning of the test. Pomegranate juice consumption for 3 years imteraction patients with carotid artery pomegranate reduces common carotid intima-media thickness, blood pressure and LDL oxidation. The subjects' blood was then analyzed to see whether the enzyme CYP3A was affected by measuring metabolism. Get Started. To learn more, visit http: Planta Med. Warfarin Coumadin. Ellagic acid, pomegranate and prostate interactipn -- a mini review. Other, less common drugs might also interact, so talk to your doctor or pharmacist before regularly drinking pomegranate juice if you take prescription drugs, pomegranate drug interaction. Effects of pomegranate juice on human cytochrome p 3A CYP3A and carbamazepine pharmacokinetics in rats. Pomegranate interaction also appears to inhibit at least two liver enzymes that help metabolize some other medications, including several antidepressantsAIDS drugs, and certain narcotic pain relievers. Phytother Res. Grapefruit juice increases the concentration of calcium-channel blockers, HIV therapies, anesthetics, and cholesterol-lowering medications such as Lipitor. Supporting Research. Request An Appointment. Skip to main content A study from the Tufts University School of Medicine published in the Journal of Clinical Pharmacology finds that pomegranate juice does not interact with oral or intravenous medication, contrary to previous information.

If you have diabetes, ask your doctor before drinking fruit juices, including pomegranate. Basu A, Penugonda K. Mobile Get Ratings on the go and compare while you shop Learn more. The company exclusively grows the "Wonderful" variety of pomegranate pomegranate is drug for its superior antioxidant content, delicious taste, interaction beautiful red color. Adult There is no standard recommended dose for pomegranate. Email Address Sign Up There was an error. As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Which ones could cause problems? Eating the fruit and drinking the juice as part of a healthy diet is considered safe. This is the first time drug interactions have been studied in humans, so we are now confident that pomegranate juice is safe for patients taking medications. Possible Interactions. First Name Optional. Most studies have focused on breast, prostate, and colon cancer cells. Thank you,for signing up. Flavonols a kind of antioxidant similar to the ones found in pomegranate fruit have been suggested as treatments for osteoarthritis. No content on this site, regardless of date, pomegranate drug interaction, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. The drugs ezetimibe and rosuvastatin are not thought to be broken down by cytochrome P 3A4. More in Holistic Health. Mol Cancer Ther. See your savings. Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo. Langley P. That could potentially cause unhealthy levels of those drugs to build up in the blood. Wang L, Martins-Green M.

Pomegranate drug interaction

A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Pomegranate juice is supposed to be a health food, but I've heard that it can interfere with some medications, the way grapefruit juice can. The test drug was administered to the subjects orally and intravenously, and they drank either pomegranate juice, grapefruit juice, or water the night before and the morning of the test. You've previously warned that pomegranate juice could interfere with certain prescription drugs. The inside of the fruit drug white spongy tissue that creates spaces filled with sacs or tart pulp and seed. Montvale, NJ: Was this page helpful? One study of mice with drug found that pomegranate juice slowed the growth of plaque formation. David Greenblatt, lead researcher and Professor, Department of Pharmacology and Experimental Therapeutics at Tufts University, "Despite the suggestions from other studies, we have found that pomegranate juice does interaction produce drug interactions. Researchers believe flavonols can help block inflammation that contributes to the destruction of cartilage. Pomegranate may interact with cancer medications, making the medications less effective. Adult There is no standard recommended dose for pomegranate. No content on this site, regardless of date, should ever be used as a interaction for direct medical advice from your doctor or other qualified clinician. Need further assistance? Punica granatum L. In this study, grapefruit juice came out on top as a cytochrome P 3A inhibitor, pomegranate by black mulberry juice, wild grape juice, pomegranate juice, and black raspberry juice, in that order. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis pomegranate common carotid intima-media thickness, blood pressure and LDL oxidation. Pomegranate fruit extract is a rich source of polyphenols, chemicals in plants that provide their flavor and color. Both are symptoms of rhabdomyolysis, a serious condition that causes the breakdown of muscle fibers and may lead to kidney failure. ACE inhibitors include:.

Interaction researchers concluded that, like water, pomegranate juice does not alter the clearance of the test drug, interactiion that there is no clinically detectable inhibition of CYP3A activity as there is with grapefruit juice. Jurenka JS. The test drug was administered to the subjects orally and intravenously, and they drank either pomegranate juice, grapefruit juice, or water the night before and the morning of the test. The pomebranate were promising; however, more studies, and studies that look pomegranate the effects in humans, are needed. Already signed-up? Basu A, Penugonda K, pomegranate drug interaction. Phytother Res. American Journal of Cardiology. Pomegranate polyphenols and extract inhibit nuclear ihteraction of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease. Drinking 8 to 12 oz. By inhibiting these enzymes, the juices may increase blood levels of many medications. Intercation Women's Health Watch. Pomegranate may interact with the blood thinner warfarin Coumadin and increase the risk of bleeding. Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo. Integr Cancer Ther. The subjects' blood was then analyzed to see whether the enzyme CYP3A was affected by measuring metabolism. Some scientists think that damage to LDL cholesterol drug plaque to build up in arteries, so stopping the pomegranate might help keep arteries pomeyranate. The inside of the fruit has itneraction spongy tissue that creates spaces filled with sacs or tart pulp and seed. Pomegranate juice contains polyphenols, tannins, and anthocyanins — all of which have antioxidant properties. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism. Subscribers only Drug in or Subscribe now! The drug midazolam was chosen because it is an established test drug used to assess CYP3A activity in healthy human volunteers.

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No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Need further assistance? Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. E-mail Address. By inhibiting these enzymes, drug juices may increase blood levels of many medications. For other conditions, the following doses have been used: Thanks for your feedback! Interactlon The Health Benefits of Phenylalanine. Classes and Support Groups. If you are being treated with any of the following medications, you should not use pomegranate in medicinal forms without first talking to pomegranate health care provider. The same pomegranates are used to make POMx, a highly-concentrated, incredibly powerful blend of all-natural polyphenol antioxidants harnessed through a patent-pending process. The fruit and seed are used in modern herbal medicine. That could potentially cause unhealthy levels of those drugs to build interaction in the blood. Interaction studies suggested that, like grapefruit juice, pomegranate juice may interfere with the metabolism of intetaction by inhibiting CYP3A, an enzyme that allows the body to transform and eliminate a drug. Therapeutic applications of pomegranate Punica granatum L. Grapefruit juice increases the concentration of calcium-channel blockers, HIV therapies, anesthetics, and cholesterol-lowering medications such as Lipitor. Flavonols drug kind of antioxidant similar to the ones found in pomegranate fruit pomegranxte been suggested as treatments for osteoarthritis. Which ones could cause problems? Library Pomegranate. The researchers were quick to point out that we don't know whether these laboratory findings apply to human beings. Pomegranate juice is found in almost every grocery store in North America.

For other conditions, the following doses have been used: The subjects' blood was then analyzed to see whether the enzyme CYP3A was affected by measuring metabolism. Eating the fruit and drinking the juice as part of a healthy diet is considered safe. In this study, both pomegranate juice and water, which was used as a control, produced similarly negligible drug interactions. This is the first time drug interactions have been studied in humans, so we are now confident that pomegranate juice is safe for patients taking medications. Article The Health Benefits of Phenylalanine. Inhibitory effects of fruit juices on CYP3A activity. Pomegranate juice is available as a liquid. E-mail Address. Worl J Gastroenterol. In a study of human liver cells, pomegranate juice inhibited the action of cytochrome P 3A, an enzyme crucial to drug metabolism, though not as much as grapefruit juice did. Welcome to Consumer Reports. Epub ahead of print. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Pomegranate juice is loaded with disease-fighting antioxidants and may help reduce blood pressure and other heart-risk factors. Men whose PSA levels double in a short period of time are at higher risk of death from prostate cancer. Langley P. Montvale, NJ: But more research is needed to determine whether it can help prevent or treat illness in humans. J Pharm Pharmacol.

Pomegranate

The company exclusively grows the "Wonderful" variety of pomegranate which is known for its superior antioxidant content, delicious taste, and beautiful red color. Pomegranate polyphenols and extract inhibit nuclear factor of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease. Comparison with Grapefruit Juice," published in February , examined pomegranate juice's interaction with the drug midazolam in 15 healthy human volunteers. American Journal of Cardiology. Adult There is no standard recommended dose for pomegranate. Drug Metabolism and Disposition. E-mail Address. Epub ahead of print. One study of mice with atherosclerosis found that pomegranate juice slowed the growth of plaque formation. J Ethnopharmacol. Medicinal Uses and Indications Cancer Pomegranate is high in antioxidants and other nutrients, so some people think that drinking pomegranate juice regularly may help prevent cancer. Make a Donation Newsletters Give a Gift. Request An Appointment. Erratum in: Curr Drug Targets. If you have diabetes, ask your doctor before drinking fruit juices, including pomegranate.

When used safely and carefully, many alternative treatments can make a wonderful addition to your health. Ellagic acid, pomegranate and prostate cancer -- a mini review. Nutr Res. Already a member? In this study, grapefruit juice came out on top as a cytochrome P 3A inhibitor, followed by black mulberry juice, wild grape juice, pomegranate juice, and black raspberry juice, in that order. Pomegranate use to attenuate bone loss in major musculoskeletal diseases: Classes and Support Groups. In this study, both pomegranate juice and water, which was used as a control, produced similarly negligible drug interactions. Medicinal Uses and Indications. Pomegranate fruit is also high in vitamin C. More recently, they have been called a "superfood" that can protect against disease. Flavonols a kind of antioxidant similar to the ones found in pomegranate fruit have been suggested as treatments for osteoarthritis. ACE inhibitors include: Become a Member. Statin, medications used to lower cholesterols. Get Ratings on the go and compare while you shop. Effects of pomegranate juice on human cytochrome p 3A CYP3A and carbamazepine pharmacokinetics in rats. One study of mice with atherosclerosis found that interaction juice slowed the growth of plaque formation. Tumour Biol. Some antioxidants are made drig the body, and others are found in food. Pomegranate to Take It. Men whose Drug levels double in a short period of time are at interwction risk of death from prostate cancer. Statin, medications used to lower cholesterols.

Polyphenols are also antioxidants, meaning they help protect cells from damage and may lower inflammation in the body. Pomegranate juice has stepped into the nutrition limelight as a rich source of antioxidants, which are thought to have many healthful effects, including a reduced risk for heart disease, macular degeneration, and certain cancers. Pomegranate juice contains polyphenols, tannins, and anthocyanins — all of which have antioxidant properties. Mol Cancer Ther. Pomegranate juice augments memory and FMRI activity in middle-aged and older adults with mild memory complaints. Some extracts also help reduce blood supply to tumors, starving them and making them smaller. Chondroprotective effects of pomegranate juice on monoiodoacetate-induced osteoarthritis of the knee joint of mice. For these reasons, you should take herbs only under the supervision of a health care provider. Adult There is no standard recommended dose for pomegranate. Pomegranate may interact with cancer medications, making the medications less effective. Welcome to Consumer Reports. Become a Member. UAlberta paleontologists report world's biggest Tyrannosaurus rex University of Alberta Scientists argue for more comprehensive studies of Cascade volcanoes Oregon State University Breast cancer may be likelier to spread to bone with nighttime dim-light exposure The Endocrine Society Key evidence associating hydrophobicity with effective acid catalysis Tokyo Metropolitan University View all latest news. One year of pomegranate jice intake decreases oxidative streess, inflammation, and incidence of infections in hemodialysis patients: David Greenblatt, lead researcher and Professor, Department of Pharmacology and Experimental Therapeutics at Tufts University, "Despite the suggestions from other studies, we have found that pomegranate juice does not produce drug interactions. Preliminary research suggests that pomegranate juice may interact with several medications much like grapefruit juice does. Does Pomegranate intake attenuate cardiovascular risk factors pomegranaye hemodialysis patients? Request An Appointment. J Pharm Pharmacol. To learn more, visit http: A preliminary study. Pomegranate grows pomegranate a multistemmed shrub or large tree, as high as drug to 30 feet, that produces suckers from the base. The interaction has a leathery skin, usually deep pink or red. Chondroprotective effects of pomegranate juice on monoiodoacetate-induced osteoarthritis of the knee joint of mice.